Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.
Broadly expressed, with highest levels in lung, testis, kidney and brain.
Contains 1 FYVE-type zinc finger. Contains 1 RUN domain.
The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.
Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting. Phosphorylated upon DNA damage, probably by ATM or ATR.