製品の概要

  • 製品名Anti-RSPH4A antibody
    RSPH4A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RSPH4A
  • アプリケーション適用あり: ICC/IF, IHC-P, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence: DVSYNNAKQK ELRFDVFQEE DSNSDYDLQQ PAPGGSEVAP SMLEITIQNA KAYLLKTSSN SGFNLYDHLS NMLTKI, corresponding to amino acids 165-240 of Human RSPH4A.

  • ポジティブ・コントロール
    • Human kidney tissue; RT4 and U51MG lysates; A431 cells

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab122159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 1 - 4 µg/ml. Using PFA/Triton X-100 fixation
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

ターゲット情報

  • 機能Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules.
  • 関連疾患Defects in RSPH4A are the cause of primary ciliary dyskinesia type 11 (CILD11) [MIM:612649]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
  • 配列類似性Belongs to the flagellar radial spoke RSP4/6 family.
  • 細胞内局在Cytoplasm > cytoskeleton > cilium axoneme. Radial spoke.
  • Information by UniProt
  • 参照データベース
  • 別名
    • A230081C05 antibody
    • CILD11 antibody
    • dJ412I7.1 antibody
    • Radial spoke head protein 4 homolog A antibody
    • Radial spoke head-like protein 3 antibody
    • RSH4A_HUMAN antibody
    • RSHL3 antibody
    • Rsph4a antibody
    • RSPH6B antibody
    see all

Anti-RSPH4A antibody 画像

  • ab122159 at 1/100 dilution staining RSPH4A in Paraffin-embedded Human Kidney tissue by Immunohistochemistry.
  • All lanes : Anti-RSPH4A antibody (ab122159) at 1/250 dilution

    Lane 1 : RT4 lysate
    Lane 2 : U251MG lysate
    Lane 3 : Human plasma
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate

    Developed using the ECL technique
  • ab122159 at 4 µg/ml staining RSPH4A in PFA/Triton X-100 fixed/permeabilized A431 cells by Immunofluorescence(green).
  • Immunohistochemical staining of Human fallopian tube shows strong positivity in ciliated cells using ab122159

Anti-RSPH4A antibody (ab122159) 使用論文

ab122159 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab122159.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"