製品の概要

  • 製品名Anti-RSPH4A antibody
    RSPH4A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RSPH4A
  • アプリケーション適用あり: ICC/IF, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 98-164 (APARQDLAAP PQSDRTTSVI PEAGTPYPDP LEQSSDKRES TPHHTSQSEG NTFQQSQQPK PHLCGRR) of Human RSPH4A.

  • ポジティブ・コントロール
    • Human bronchus tissue; A-431 cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab122158 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 1 - 4 µg/ml. Fixation/Permeabilization: PFA/Triton X-100
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules.
  • 関連疾患Defects in RSPH4A are the cause of primary ciliary dyskinesia type 11 (CILD11) [MIM:612649]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
  • 配列類似性Belongs to the flagellar radial spoke RSP4/6 family.
  • 細胞内局在Cytoplasm > cytoskeleton > cilium axoneme. Radial spoke.
  • Information by UniProt
  • 参照データベース
  • 別名
    • A230081C05 antibody
    • CILD11 antibody
    • dJ412I7.1 antibody
    • Radial spoke head protein 4 homolog A antibody
    • Radial spoke head-like protein 3 antibody
    • RSH4A_HUMAN antibody
    • RSHL3 antibody
    • Rsph4a antibody
    • RSPH6B antibody
    see all

Anti-RSPH4A antibody 画像

  • ab122158, at 1/75, staining RSPH4A in paraffin embedded Human bronchus by Immunohistochemistry.
  • ab122158, at 4 µg/ml, staining RSPH4A (green) in PFA-fixed, Triton-permeabilized Human A-431 cells by Immunofluorescence.

Anti-RSPH4A antibody (ab122158) 使用論文

ab122158 has not yet been referenced specifically in any publications.

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