製品の概要

  • 製品名RS 102895 hydrochloride
  • 製品の詳細
    Selective CCR2 receptor antagonist
  • 生理活性の詳細Selective CCR2 receptor antagonist (IC50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC50 values are 32 and 130 nM, respectively). Active in vivo.
  • 精製度> 99%

製品の特性

  • 体系名1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride
  • 分子量426.86
  • 構造式Chemical Structure
  • 分子式C21H21F3N2O2.HCl
  • CAS 番号1173022-16-6
  • 保存方法Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 50 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記Cl.FC(F)(F)c1ccc(cc1)CCN2CCC4(CC2)OC(=O)Nc3ccccc34
  • 由来

    Synthetic

    RS 102895 hydrochloride (ab120812) 使用論文

    This product has been referenced in:
    • Rehni AK & Singh N Ammonium pyrrolidine dithiocarbamate and RS 102895 attenuate opioid withdrawal in vivo and in vitro. Psychopharmacology (Berl) 220:427-38 (2012). Read more (PubMed: 21931991) »
    • Rehni AK & Singh TG Involvement of CCR-2 chemokine receptor activation in ischemic preconditioning and postconditioning of brain in mice. Cytokine 60:83-9 (2012). Read more (PubMed: 22704692) »
    • Mirzadegan T  et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem 275:25562-71 (2000). Read more (PubMed: 10770925) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"