製品の概要

  • 製品名Anti-RPGRIP1L antibody
    RPGRIP1L 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RPGRIP1L
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide selected from the N-terminal region of Human RPGRIP1L conjugated to KLH (NP_056087.2).

  • ポジティブ・コントロール
    • 293 cell line lysates.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab91467 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab91467 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 151 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1 and NPHP4 (By similarity). Does not seem to be strictly required for ciliogenesis.
    • 組織特異性Ubiquitously expressed with relatively high level of expression in hypothalamus and islet. During early development, expressed in multiple organs including brain, eye, forelimb and kidney.
    • 関連疾患Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Overlapping clinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of various organ, and a complex range of anatomical and functional defects of the central and peripheral nervous system. The ciliopathy range of diseases includes Meckel-Gruber syndrome, Bardet-Biedl syndrome, Joubert syndrome, nephronophtisis, Senior-Loken syndrome, and Jeune asphyxiating thoracic dystrophy among others. Single-locus allelism is insufficient to explain the variable penetrance and expressivity of such disorders, leading to the suggestion that variations across multiple sites of the ciliary proteome, including RPGRIP1L, influence the clinical outcome.
      Joubert syndrome 7
      Meckel syndrome 5
      COACH syndrome
    • 配列類似性Belongs to the RPGRIP1 family.
      Contains 2 C2 domains.
    • 細胞内局在Cytoplasm. Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > cilium axoneme. Cytoplasm > cytoskeleton > microtubule organizing center > centrosome. Cell junction > tight junction. In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CORS 3 antibody
      • CORS3 antibody
      • Fantom antibody
      • FTM antibody
      • FTM_HUMAN antibody
      • JBTS 1 antibody
      • JBTS 7 antibody
      • JBTS1 antibody
      • JBTS7 antibody
      • Joubert syndrome 1 antibody
      • Joubert syndrome 7 antibody
      • Meckel syndrome, type 1 antibody
      • Meckel syndrome, type 5 antibody
      • MKS 5 antibody
      • MKS5 antibody
      • Nephrocystin-8 antibody
      • NPHP 8 antibody
      • NPHP8 antibody
      • Protein fantom antibody
      • Retinitis pigmentosa GTPase regulator interacting protein 1 like antibody
      • RPGR interacting protein 1 like protein antibody
      • RPGR-interacting protein 1-like protein antibody
      • RPGRIP1 like protein antibody
      • RPGRIP1-like protein antibody
      • Rpgrip1l antibody
      see all

    Anti-RPGRIP1L antibody 画像

    • Anti-RPGRIP1L antibody (ab91467) at 1/100 dilution + 293 cell line lysates at 35 µg

      Predicted band size : 151 kDa

    Anti-RPGRIP1L antibody (ab91467) 使用論文

    ab91467 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab91467.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"