製品の概要

  • 製品名Anti-RP1 antibody
  • 製品の詳細
    Rabbit polyclonal to RP1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 1254-1400 of Human RP1.

  • ポジティブ・コントロール
    • Human kidney tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab122781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher order stacking of outer segment disks along the photoreceptor axoneme.
  • 組織特異性Expressed in retina. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, spleen and pancreas.
  • 関連疾患Defects in RP1 are the cause of retinitis pigmentosa type 1 (RP1) [MIM:180100]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 配列類似性Contains 2 doublecortin domains.
  • ドメインThe doublecortin domains, which mediate interaction with microtubules, are required for regulation of microtubule polymerization and function in photoreceptor differentiation.
  • 細胞内局在Cytoplasm > cytoskeleton > cilium axoneme. Cell projection > cilium > photoreceptor outer segment. Specifically localized in the connecting cilia of rod and cone photoreceptors.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DCDC4A antibody
    • ORP1 antibody
    • Oxygen-regulated protein 1 antibody
    • Retinitis pigmentosa 1 protein antibody
    • Retinitis pigmentosa RP1 protein antibody
    • RP1 antibody
    • RP1_HUMAN antibody
    see all

Anti-RP1 antibody 画像

  • ab122781, at 1/1000 dilution, staining RP1 in Paraffin Embedded Human kidney tissue by Immunohistochemistry.

Anti-RP1 antibody (ab122781) 使用論文

ab122781 has not yet been referenced specifically in any publications.

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