製品の概要

  • 製品名Anti-ROR alpha antibody
    ROR alpha 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ROR alpha
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to N terminal amino acids 31-70 of Human ROR alpha

  • ポジティブ・コントロール
    • Human breast carcinoma tissue, extracts from HeLa and COS-7 cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab70061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 63 kDa (predicted molecular weight: 63 kDa).
ELISA 1/40000.
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives.
  • 組織特異性Widely expressed in a number of tissues.
  • 配列類似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 翻訳後修飾Phosphorylation by PKC in neurons inhibits transcriptional activity. Phosphorylated on Thr-216 by ERK2 in vitro.
    Sumoylated by SENP1 and SENP2. Sumoylation, promoted by PIAS2, PIAS3, PIASy but not PIAS1, enhances the transcriptional activity. Desumoylated by SENP1.
    Ubiquitinated. Ubiquitination is required for efficient transcriptional activity and is prevented by Hairless.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • fhl2a antibody
    • NR1F1 antibody
    • Nuclear receptor ROR-alpha antibody
    • Nuclear receptor RZR-alpha antibody
    • Nuclear receptor subfamily 1 group F member 1 antibody
    • RAR-related orphan receptor A antibody
    • Retinoid-related orphan receptor-alpha antibody
    • Rora antibody
    • RORA_HUMAN antibody
    • RZR-ALPHA antibody
    • RZRA antibody
    see all

Anti-ROR alpha antibody 画像

  • All lanes : Anti-ROR alpha antibody (ab70061) at 1/500 dilution

    Lane 1 : extract from HeLa cells
    Lane 2 : extract from COS-7 cells
    Lane 3 : extract from COS-7 cells with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 63 kDa
    Observed band size : 63 kDa
  • Human breast carcinoma tissue with ab70061 at 1/50 dilution, with and without the immunising peptide.

Anti-ROR alpha antibody (ab70061) 使用論文

ab70061 has not yet been referenced specifically in any publications.

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This antibody can react with isoform 2.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"