製品の概要

  • 製品名Anti-RNPS1 antibody
    RNPS1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to RNPS1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: PKPTKVHIGR LTRNVTKDHI MEIFSTYGKI KMIDMPVERM HPHLSKGYAY VEFENPDEAE KALKHMDGGQ IDGQEITATA VL, corresponding to amino acids 158-240 of Human RNPS1

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56806 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Part of pre- and post-splicing multiprotein mRNP complexes. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
    • 組織特異性Ubiquitous.
    • 配列類似性Belongs to the splicing factor SR family.
      Contains 1 RRM (RNA recognition motif) domain.
    • 翻訳後修飾Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro.
    • 細胞内局在Nucleus. Nucleus speckle. Cytoplasm. Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
    • Information by UniProt
    • 参照データベース
    • 別名
      • E5.1 antibody
      • MGC117332 antibody
      • RNA binding protein S1 serine rich domain antibody
      • RNA binding protein with serine rich domain 1 antibody
      • RNA-binding protein with serine-rich domain 1 antibody
      • RNPS 1 antibody
      • rnps1 antibody
      • RNPS1_HUMAN antibody
      • SR protein antibody
      • SR related protein LDC2 antibody
      • SR-related protein LDC2 antibody
      see all

    Anti-RNPS1 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab56806 RNPS1 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    Anti-RNPS1 antibody (ab56806) 使用論文

    ab56806 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"