製品の概要

  • 製品名Anti-RNF7 antibody
    RNF7 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RNF7
  • 特異性Sufficient sequence differences exist to suggest that this antibody would not react with other RING box proteins such as ROC1 and APC11.
  • アプリケーション適用あり: ELISA, Flow Cyt, IP, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide:

    CQQDWVVQRIGK

    conjugated to KLH, corresponding to C terminal amino acids 102-113 of Human RNF7

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab34873 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/2000 - 1/10000.
Flow Cyt Use at an assay dependent concentration. PubMed: 24786833ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
WB 1/500 - 1/1000. Detects a band of approximately 12.6 kDa (predicted molecular weight: 13 kDa).

ターゲット情報

  • 機能Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
  • 組織特異性Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung.
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Belongs to the RING-box family.
    Contains 1 RING-type zinc finger.
  • ドメインThe RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.
  • 翻訳後修飾Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CKBBP 1 antibody
    • CKBBP1 antibody
    • CKII beta binding protein 1 antibody
    • CKII beta-binding protein 1 antibody
    • Rbx 2 antibody
    • Rbx2 antibody
    • RBX2_HUMAN antibody
    • Regulator of cullins 2 antibody
    • RING box protein 2 antibody
    • RING finger protein 7 antibody
    • RING-box protein 2 antibody
    • RNF 7 antibody
    • RNF7 antibody
    • ROC 2 antibody
    • ROC2 antibody
    • SAG antibody
    • Sensitive to apoptosis gene antibody
    • Sensitive to apoptosis gene protein antibody
    • Zinc RING finger protein SAG antibody
    see all

Anti-RNF7 antibody (ab34873) 使用論文

This product has been referenced in:
  • Chang SC & Ding JL Ubiquitination by SAG regulates macrophage survival/death and immune response during infection. Cell Death Differ N/A:N/A (2014). Flow Cyt . Read more (PubMed: 24786833) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab34873.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"