製品の概要

  • 製品名Anti-RNF6 antibody
    RNF6 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to RNF6
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: MNQSRSRSDG GSEETLPQDH NHHENERRWQ QERLHREEAY YQFINELNDE DYRLMRDHNL LGTPGEITSE ELQQRLDGVK EQLASQPDLR DGTNYRDSEV , corresponding to amino acids 1-101 of Human RNF6

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab58293 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
    • 組織特異性Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
    • パスウェイProtein modification; protein ubiquitination.
    • 関連疾患Defects in RNF6 may be a cause of esophageal cancer (ESCR) [MIM:133239]. A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
    • 配列類似性Belongs to the RNF12 family.
      Contains 1 RING-type zinc finger.
    • 発生段階Expressed in embryo and adult testis.
    • 細胞内局在Nucleus. Cytoplasm. Cell projection > axon. Nucleus > PML body. Localizes to the PML nuclear bodies in Sertoli cells.
    • Information by UniProt
    • 参照データベース
    • 別名
      • E3 ubiquitin-protein ligase RNF6 antibody
      • Ring finger protein (C3H2C3 type) 6 antibody
      • Ring finger protein 6 antibody
      • RING H2 protein antibody
      • RING H2 protein RNF6 antibody
      • RNF 6 antibody
      • RNF6 antibody
      • RNF6_HUMAN antibody
      • SPG2 antibody
      see all

    Anti-RNF6 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab58293 RNF6 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-RNF6 antibody (ab58293) 使用論文

    ab58293 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab58293.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"