製品の概要

  • 製品名Anti-RNF168 antibody
    RNF168 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RNF168
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    18 amino acid peptide from near the carboxy terminus of Human RNF168 (NP_689830).

  • ポジティブ・コントロール
    • Human Brain Tissue Lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 65 kDa.

ターゲット情報

  • 機能E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1.
  • パスウェイProtein modification; protein ubiquitination.
  • 関連疾患Defects in RNF168 are the cause of Riddle syndrome (RIDDLES) [MIM:611943]. Riddle syndrome is characterized by increased radiosensitivity, immunodeficiency, mild motor control and learning difficulties, facial dysmorphism, and short stature. Defects are probably due to impaired localization of TP53BP1 and BRCA1 at DNA lesions.
  • 配列類似性Belongs to the RNF168 family.
    Contains 1 RING-type zinc finger.
  • ドメインThe MIU motifs (motif interacting with ubiquitin) mediate the interaction with ubiquitin and the localization at sites of DNA damage.
  • 細胞内局在Nucleus. Localizes to sites of DNA damage.
  • Information by UniProt
  • 参照データベース
  • 別名
    • E3 ubiquitin protein ligase RNF168 antibody
    • E3 ubiquitin-protein ligase RNF168 antibody
    • FLJ35794 antibody
    • FLJ39749 antibody
    • RING finger protein 168 antibody
    • RN168_HUMAN antibody
    • RNF 168 antibody
    • Rnf168 antibody
    see all

Anti-RNF168 antibody 画像

  • Anti-RNF168 antibody (ab106389) at 1 µg/ml + Human Brain Tissue Lysate at 15 µg

    Predicted band size : 65 kDa

Anti-RNF168 antibody (ab106389) 使用論文

ab106389 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab106389.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"