製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to RNF156
  • アプリケーション
    適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region between amino acids 505-555 of Human RNF156 (NP_001135761.1).

  • ポジティブ・コントロール
    • HeLa whole cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab101997 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 2-5 µg/mg of lysate.
  • 追加情報
    Is unsuitable for WB.
  • ターゲット情報

    • 機能
      E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
    • パスウェイ
      Protein modification; protein ubiquitination.
    • 配列類似性
      Contains 1 RING-type zinc finger.
    • ドメイン
      The RING finger is required for ubiquitin ligase activity.
    • 翻訳後修飾
      Autoubiquitinated in vitro.
    • 細胞内局在
      Cytoplasm > cytosol. Cell membrane; Early endosome. The endosomal localization is dependent on the interaction with TSG101 and Cytoplasm > cytosol. Nucleus. Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
    • Information by UniProt
    • 参照データベース
    • 別名
      • E3 ubiquitin-protein ligase MGRN1 antibody
      • KIAA0544 antibody
      • Mahogunin ring finger 1 antibody
      • Mahogunin RING finger protein 1 antibody
      • MGRN 1 antibody
      • Mgrn1 antibody
      • MGRN1_HUMAN antibody
      • Probable E3 ubiquitin protein ligase MGRN1 antibody
      • RING finger protein 156 antibody
      • RNF 156 antibody
      see all

    プロトコール

    参考文献

    ab101997 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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