製品の概要

  • 製品名Anti-RNF139 antibody
    RNF139 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to RNF139
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: HYFHALCLRK WLYIQDTCPM CHQKVYIEDD IKDNSNVSNN NGFIPPNETP EEAVREAAAE SDRELNEDDS TDCDDDVQRE RNGVIQHTGA AAEEFNDDTD , corresponding to amino acids 565-665 of Human RNF139

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性RNF139 is a multi-membrane spanning protein E3 ubiquitin ligase which is mutated in clear-cell renal carcinomas. It contains a sterol-sensing domain and a RING-H2 motif essential for ubiquitin ligase activity. It is a potential tumor suppressor for renal cell carcinoma. Human kidney cells are growth inhibited by RNF139. Inhibition is manifested by G2/M arrest and is dependent upon the ubiquitin ligase activity of the RING domain. Expression of RNF139 represses genes involved in cholesterol and fatty acid biosynthesis that are transcriptionally regulated by the sterol response element binding proteins (SREBPs). RNF139 modulation of SREBP activity comprises a novel regulatory link between growth control and the cholesterol/lipid homeostasis pathway.
    • 細胞内局在Endoplasmic reticulum membrane; Multi-pass membrane protein.
    • 参照データベース
    • 別名
      • E3 ubiquitin-protein ligase RNF139 antibody
      • HRCA1 antibody
      • RCA1 antibody
      • Ring finger protein 139 antibody
      • Translocation in renal carcinoma on chromosome 8 protein antibody
      • TRC8 antibody
      see all

    Anti-RNF139 antibody 画像

    • RNF139 antibody (ab56924) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human tonsil.


    • Predicted band size : 76 kDa
      RNF139 antibody (ab56924) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

    Anti-RNF139 antibody (ab56924) 使用論文

    This product has been referenced in:
    • Gimelli S  et al. The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma. Mol Cancer 8:52 (2009). IHC-P ; Human . Read more (PubMed: 19642973) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"