製品の概要

  • 製品名
    Anti-RNA Helicase A antibody
    RNA Helicase A 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to RNA Helicase A
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Xenopus laevis, Pufferfish, Zebrafish, Orangutan
  • 免疫原

    Synthetic peptide:

    TEGRNALIHKSSVNC

    , corresponding to internal sequence amino acids 1015-1029 of human RNA Helicase A (NP_001348.2).

  • ポジティブ・コントロール
    • HeLa nuclear lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab87608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 140 kDa (predicted molecular weight: 141 kDa).

ターゲット情報

  • 機能
    Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability.
  • 配列類似性
    Belongs to the DEAD box helicase family. DEAH subfamily.
    Contains 2 DRBM (double-stranded RNA-binding) domains.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • ドメイン
    The MTAD domain mediates interaction with the RNA polymerase II holoenzyme. The NTD domain is necessary and sufficient for nucleo-cytoplasmic shuttling and interaction with HRMT1L2 and SMN1.
  • 翻訳後修飾
    Methylated. HRMT1L2 mediated methylation of undefined Arg residues in the NTD is required for nuclear localization.
    May be phosphorylated by PRKDC/XRCC7. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在
    Nucleus > nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Can shuttle between nucleus and cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ATP dependent RNA helicase A antibody
    • ATP-dependent RNA helicase A antibody
    • DDX 9 antibody
    • DDX9 antibody
    • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 9 antibody
    • DEAD/H box 9 antibody
    • DEAD/H box polypeptide 9 antibody
    • DEAH (Asp Glu Ala His) box polypeptide 9 antibody
    • DEAH box polypeptide 9 antibody
    • DEAH box protein 9 antibody
    • DHX 9 antibody
    • dhx9 antibody
    • DHX9_HUMAN antibody
    • Leukophysin antibody
    • LKP antibody
    • NDH 2 antibody
    • NDH II antibody
    • NDH2 antibody
    • NDHII antibody
    • Nuclear DNA helicase II antibody
    • RHA antibody
    see all

画像

  • Anti-RNA Helicase A antibody (ab87608) at 1 µg/ml + HeLa nuclear lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 141 kDa
    Observed band size : 140 kDa (why is the actual band size different from the predicted?)

プロトコール

参考文献

ab87608 has not yet been referenced specifically in any publications.

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