Function: Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.
Tissue specificity: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 1 CARD domain.
Contains 1 protein kinase domain.
PTM: Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination catalyzed by ITCH.
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in the following tested applications.
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Use at an assay dependent dilution.
RIP2 overexpression 293T lysate (whole cell) 画像
RIP2 overexpression 293T lysate (whole cell) (ab94131) 使用論文
has not yet been referenced specifically in any publications.
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