製品の概要

  • 製品名Anti-RIP2 antibody
    RIP2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RIP2
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide:

    PTIPYHKLADLRYLSRGASG

    , corresponding to amino acids 11/30 of Human RIP2. (Peptide available as ab8463.)

  • ポジティブ・コントロール
    • A431 or K562 whole cell lysate An approximately60 kDa band can be detected.

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab8428 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Detects a band of approximately 60 kDa.Can be blocked with Human RIP2 peptide (ab8463).
ICC/IF Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.
  • 組織特異性Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
  • 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
    Contains 1 CARD domain.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
    Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination catalyzed by ITCH.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CARD 3 antibody
    • CARD carrying kinase antibody
    • CARD containing ICE associated kinase antibody
    • CARD containing IL 1 beta ICE kinase antibody
    • CARD containing IL1 beta ICE kinase antibody
    • CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase antibody
    • CARD containing interleukin 1 beta converting enzyme associated kinase antibody
    • CARD-containing IL-1 beta ICE-kinase antibody
    • CARD-containing interleukin-1 beta-converting enzyme-associated kinase antibody
    • CARD3 antibody
    • CARDIAK antibody
    • CCK antibody
    • CLARP kinase antibody
    • GIG 30 antibody
    • GIG30 antibody
    • Growth inhibiting gene 30 antibody
    • Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase antibody
    • Receptor interacting protein 2 antibody
    • Receptor interacting serine threonine kinase 2 antibody
    • Receptor interacting serine/threonine protein kinase 2 antibody
    • Receptor-interacting protein 2 antibody
    • Receptor-interacting serine/threonine-protein kinase 2 antibody
    • RICK antibody
    • RIP 2 antibody
    • RIP like interacting CLARP kinase antibody
    • RIP-2 antibody
    • RIP-like-interacting CLARP kinase antibody
    • RIPK 2 antibody
    • Ripk2 antibody
    • RIPK2_HUMAN antibody
    • TNFRSF antibody
    see all

Anti-RIP2 antibody 画像

  • All lanes : Anti-RIP2 antibody (ab8428) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : K562 whole cell lysate


    Observed band size : 60 kDa (why is the actual band size different from the predicted?)
  • ab8428 at 10µg/ml staining RIP2 in A431 cells by ICC/IF 

Anti-RIP2 antibody (ab8428) 使用論文

This product has been referenced in:
  • Hollenbach E  et al. Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease. J Biol Chem 280:14981-8 (2005). Read more (PubMed: 15691843) »

See 1 Publication for this product

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There are currently no Abreviews or Questions for ab8428.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"