製品の概要

  • 製品名Anti-RICTOR antibody
    RICTOR 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RICTOR
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to a sequence within amino acids 1648-1708 of Human RICTOR (NP_689969).

  • ポジティブ・コントロール
    • 293T, H1299, HeLaS3, HepG2, Molt4 and Raji cell lysates and A431 whole cell lystes. HeLa cells.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 192 kDa.
ICC/IF 1/100 - 1/200.

ターゲット情報

  • 機能Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
  • 配列類似性Belongs to the RICTOR family.
  • 翻訳後修飾Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AVO3 antibody
    • AVO3 homolog antibody
    • DKFZp686B11164 antibody
    • hAVO3 antibody
    • KIAA1999 antibody
    • Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) antibody
    • mAVO3 antibody
    • MGC39830 antibody
    • PIA antibody
    • Pianissimo antibody
    • Rapamycin insensitive companion of mTOR antibody
    • Rapamycin-insensitive companion of mTOR antibody
    • Rictor antibody
    • RICTR antibody
    • RICTR_HUMAN antibody
    • RPTOR independent companion of MTOR complex 2 antibody
    • TORC2 specific protein AVO3 antibody
    see all

Anti-RICTOR antibody 画像

  • Anti-RICTOR antibody (ab96687) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 192 kDa
  • ab96687 at 1/200 dilution staining RICTOR in HeLa cells by Immunofluorescence, Paraformaldehyde fixed. Lower image is merged with DNA probe.

Anti-RICTOR antibody (ab96687) 使用論文

ab96687 has not yet been referenced specifically in any publications.

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