製品の概要

  • 製品名Anti-RICH2 antibody
  • 製品の詳細
    Rabbit polyclonal to RICH2
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide: MKKQFNRMRQ LANQTVGRA E KTEVLSED LL QVEKRLE LVK QVSHST HKKL TACLQ GQQGA, corresponding to N terminal amino acids 1-60 of Mouse RICH2

  • ポジティブ・コントロール
    • purified RICH2 protein

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーAntibody stabilization buffer
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab93627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: <1/10000.
    WB: >1/500. Detects a band of approximately 92 kDa (predicted molecular weight: 89 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性RICH2, Rho GTPase-activating protein interacting with CIP homologue protein 2, is a member Rho GTPase activating protein RICH family. This family of protein is one of the major regulators of Rho GTPases in all eukaryotes. In addition to their role as specific negative regulators of Rho protein signaling pathways, they are crucial in the differentiation, growth and organization of cell cytoskeleton, neuronal development and synaptic functions. RICH2 is located at mouse chromosome 11B3 and as a GTPase activator for the Rho-type GTPases, it converts them to an inactive GDP-bound state. Recent reports have identified RICH2 as a GTPase activator for Cdc42 and Rac1. RICH2 and different isoforms of RICH1 share two conserved domains, an N-terminal BAR domain and Rho/Rac/cdc42 GAP domain. The BAR domain of RICH2 binds membranes and is capable of inducing membrane tabulation. As a member of RICH family of proteins, RICH2 plays a crucial role in linking CD317/tetherin to the apical actin network. Knocking down the expression of RICH2 in cells usually results in loss of apical actin network. These cells exhibited similar characteristics that were seen in the CD317 knockdown cells. These characteristics include subsequent loss of apical microvilli, increase in actin bundles at the basal surface, reduction in cell height without any loss of tight junctions or transepithelial resistance or any change in the distribution of apical and basolateral marker proteins. Overexpression of RICH2 leads to a loss of Ras-induced membrane ruffles.
    • 細胞内局在Cytoplasmic
    • 参照データベース
    • 別名
      • KIAA0672 antibody
      • NPC A 10 antibody
      • Rho GTPase activating protein RICH2 antibody
      • Rho type GTPase activating protein RICH2 antibody
      • RhoGAP interacting with CIP4 homologs protein 2 antibody
      see all

    Anti-RICH2 antibody 画像

    Anti-RICH2 antibody (ab93627) 使用論文

    ab93627 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab93627.
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