製品の概要

  • 製品名Anti-RIC8A antibody
    RIC8A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RIC8A
  • アプリケーション適用あり: ICC/IF, IP, IHC-P, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 528 and 537 of Human RIC8A (NP_068751).

  • ポジティブ・コントロール
    • A431, H1299, HeLa, HepG2 and Raji cell lines; Adrenal cortical tumor

法規制情報

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab97808 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent concentration. PubMed: 24466196
IP Use at an assay dependent concentration. PubMed: 24466196
IHC-P 1/100 - 1/500.
WB 1/500 - 1/3000. Predicted molecular weight: 60 kDa.

ターゲット情報

  • 機能Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
  • 配列類似性Belongs to the synembryn family.
  • 細胞内局在Cytoplasm. Cell membrane. Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity).
  • Information by UniProt
  • 参照データベース
  • 別名
    • MGC104517 antibody
    • MGC131931 antibody
    • MGC148073 antibody
    • MGC148074 antibody
    • Protein Ric-8A antibody
    • resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) antibody
    • RIC8 antibody
    • RIC8A antibody
    • RIC8A_HUMAN antibody
    • Synembryn-A antibody
    see all

Anti-RIC8A antibody 画像

  • All lanes : Anti-RIC8A antibody (ab97808) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 60 kDa
  • ab97808, at a 1/100 dilution, staining RIC8A in paraffin embedded Adrenal cortical tumor by Immunohistochemistry.

Anti-RIC8A antibody (ab97808) 使用論文

This product has been referenced in:
  • Boularan C  et al. Resistance to inhibitors of cholinesterase (Ric)-8A and Gai contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity. PLoS One 9:e86680 (2014). WB, IP, ICC/IF ; Human . Read more (PubMed: 24466196) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"