Highly potent cell-permeable dynamin I GTPase activity inhibitor (IC50 values are 7.1 and 30.3 μM at dynamin I and dynamin II, respectively). Blocks clathrin-mediated endocytosis of transferrin when applied for 30 minutes to U2OS cells in culture (IC50 = 7.0 μM). Rhodadyn™ B10 negative control also available (ab120796).
Robertson J et al. The rhodadyn™ a new class of small molecule inhibitors of dynamin GTPase. ACS Med. Chem (2012).
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