製品の概要

  • 製品名Anti-RGS9 antibody
    RGS9 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RGS9
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 148-178 of Human RGS9 (NP_001075424.1, NP_003826.2).

  • ポジティブ・コントロール
    • NCI-H460 cell line lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab123273 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab123273 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 77 kDa.

ターゲット情報

  • 機能Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction.
  • 組織特異性Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).
  • 関連疾患Defects in RGS9 are a cause of prolonged electroretinal response suppression (PERRS) [MIM:608415]; also known as bradyopsia. PERRS is characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.
  • 配列類似性Contains 1 DEP domain.
    Contains 1 G protein gamma domain.
    Contains 1 RGS domain.
  • ドメインIn photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments.
  • 翻訳後修飾Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition.
  • 細胞内局在Membrane. Isoform 3 is targeted to the membrane via its interaction with RGS9BP.
  • Information by UniProt
  • 参照データベース
  • 別名
    • PERRS antibody
    • R9AP antibody
    • Regulator of G protein signalling 9 antibody
    • Regulator of G-protein signaling 9 antibody
    • RGS9 antibody
    • RGS9_HUMAN antibody
    • RGS9L antibody
    see all

Anti-RGS9 antibody 画像

  • Anti-RGS9 antibody (ab123273) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

    Predicted band size : 77 kDa

Anti-RGS9 antibody (ab123273) 使用論文

ab123273 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab123273.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"