製品の概要

  • 製品名Anti-RGS2 antibody
    RGS2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RGS2
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Pig
  • 免疫原

    Synthetic peptide: MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ conjugated to KLH, corresponding to amino acids 1-50 of Human RGS2 (NP_002914.1).

  • ポジティブ・コントロール
    • Human brain (cortex) tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 24 kDa.
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).
  • 組織特異性Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
  • 配列類似性Contains 1 RGS domain.
  • 翻訳後修飾Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
  • 細胞内局在Cell membrane. Mitochondrion and Cell membrane. Cytoplasm. Nucleus, nucleolus.
  • Information by UniProt
  • 参照データベース
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Anti-RGS2 antibody 画像

  • ab115684 at 20µg/ml staining RGS2 in Formalin-fixed, Paraffin-embedded Human brain (cortex) tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-RGS2 antibody (ab115684) 使用論文

ab115684 has not yet been referenced specifically in any publications.

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