製品の概要

  • 製品名
    Anti-RGS17 / RGSZ2 antibody
    RGS17 / RGSZ2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RGS17 / RGSZ2
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide: EVSLDSRVRE VINRNLLDPN PHMYEDAQLQ IYTLMHRDSF PRFLNSQIYK SFVESTAGSS SES, corresponding to amino acids 148-210 of Human RGS17/ RGSZ2 (NP_036551).

  • ポジティブ・コントロール
    • 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji cell lysates

法規制情報

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 20% Glycerol, 1% BSA, PBS, pH 7.0
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab96675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 24 kDa.

ターゲット情報

  • 機能
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
  • 組織特異性
    Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.
  • 配列類似性
    Contains 1 RGS domain.
  • 翻訳後修飾
    Fatty acylated. Heavily palmitoylated in the cysteine string motif.
    N- and O-glycosylated in synapsomal membranes.
    Serine phosphorylated in synapsomal membranes.
    Sumoylated by SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.
  • 細胞内局在
    Membrane. Nucleus. Cytoplasm. Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation.
  • Information by UniProt
  • 参照データベース
  • 別名
    • hRGS17 antibody
    • Regulator of G protein signalling 17 antibody
    • Regulator of G protein signalling Z2 antibody
    • Regulator of G-protein signaling 17 antibody
    • RGS-17 antibody
    • RGS17 antibody
    • RGS17_HUMAN antibody
    • RGSZ2 antibody
    see all

画像

  • Anti-RGS17 / RGSZ2 antibody (ab96675) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size: 24 kDa



    12% SDS PAGE

プロトコール

参考文献

ab96675 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab96675.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録