製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to RGS1
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-NLLNDLQANSLK

    (with a Cysteine residue linker), corresponding to C terminal amino acids 198-209 of Human RGS1 (Q08116).

  • ポジティブ・コントロール
    • HepG2 lysate, Human Small Intestine and Human Thymus tissues

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab117077 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 24 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.
  • 組織特異性
    B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
  • 配列類似性
    Contains 1 RGS domain.
  • 翻訳後修飾
    Could be phosphorylated. Might be functionally regulated by protein kinase(s).
  • Information by UniProt
  • 参照データベース
  • 別名
    • 1R20 antibody
    • B cell activation protein BL34 antibody
    • B-cell activation protein BL34 antibody
    • BL34 antibody
    • Early response protein 1R20 antibody
    • IER 1 antibody
    • IER1 antibody
    • Immediate early response 1 B cell specific antibody
    • immediate-early response 1, B-cell specific antibody
    • IR20 antibody
    • Regulator of G protein signalling 1 antibody
    • Regulator of G-protein signaling 1 antibody
    • RGS 1 antibody
    • RGS1 antibody
    • RGS1_HUMAN antibody
    see all

画像


  • Developed using the ECL technique

    Predicted band size : 24 kDa
  • Human Small Intestine (formalin-fixed, paraffin-embedded) stained with ab117077 followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen
  • Human Thymus (formalin-fixed, paraffin-embedded) stained with ab117077 followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

参考文献

ab117077 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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