製品の概要

  • 製品名Anti-RFXANK antibody
    RFXANK 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to RFXANK
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 93-123 of Human RFXANK (NP_604389.1, NP_003712.1).

  • ポジティブ・コントロール
    • WiDr cell line lysates

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab124068 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab124068 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 28 kDa.

ターゲット情報

  • 機能Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
  • 組織特異性Ubiquitous.
  • 関連疾患Defects in RFXANK are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
  • 配列類似性Contains 5 ANK repeats.
  • ドメインThe third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ANKRA1 antibody
    • Ankyrin repeat containing regulatory factor X associated protein antibody
    • Ankyrin repeat family A protein 1 antibody
    • BLS antibody
    • DNA-binding protein RFXANK antibody
    • F14150_1 antibody
    • MGC138628 antibody
    • Regulatory factor X associated ankyrin containing protein antibody
    • Regulatory factor X subunit B antibody
    • Regulatory factor X, ankyrin repeat containing antibody
    • Regulatory factor X-associated ankyrin-containing protein antibody
    • RFX Bdelta4 antibody
    • RFX-B antibody
    • RFXANK antibody
    • RFXB antibody
    • RFXB delta 4 antibody
    • RFXK_HUMAN antibody
    see all

Anti-RFXANK antibody 画像

  • Anti-RFXANK antibody (ab124068) at 1/100 dilution + WiDr cell line lysates at 35 µg

    Predicted band size : 28 kDa

Anti-RFXANK antibody (ab124068) 使用論文

ab124068 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab124068.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"