製品の概要

  • 製品名RFX5 Kit
  • 種交差性
    Human RFX5 from a variety of fibroblast and B-cell lysates.
  • 製品の概要

    Anti-RFX5 (N-terminal specific) may react with unknown minor bands at 85 kDa and 55 kDa.

  • アプリケーション適用あり: ELISA, IP, WBmore details

法規制情報

製品の特性

  • 機能Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
  • 組織特異性Ubiquitous.
  • 関連疾患Defects in RFX5 are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
  • 配列類似性Belongs to the RFX family.
    Contains 1 RFX-type winged-helix DNA-binding domain.
  • ドメインThe N-terminus is required for dimer formation, association with RFXANK and RFXAP, assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperative binding between the RFX complex and NF-Y.
  • 翻訳後修飾Phosphorylated.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 別名
    • DNA binding protein RFX 5
    • DNA binding protein RFX5
    • DNA-binding protein RFX5
    • Influences HLA class II expression
    • Regulatory factor X 5
    • Regulatory factor X subunit 5
    • Regulatory factor X, 5 (influences HLA class II expression)
    • RFX 5
    • RFX5
    • Rfx5 protein
    • RFX5_HUMAN
    see all

アプリケーション

Our Abpromise guarantee covers the use of ab7544 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration.

A minor band at 68 kDa may be detected which may represent an RFX5 breakdown product or unmodified RFX5

EMSA Use at an assay dependent concentration.

RFX5 Kit (ab7544) 使用論文

ab7544 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab7544.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"