製品の概要

  • 製品名Anti-RFX5 antibody
    RFX5 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to RFX5
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 516-617 of Human RFX5

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab57920 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.
    • 組織特異性Ubiquitous.
    • 関連疾患Defects in RFX5 are a cause of bare lymphocyte syndrome type 2 (BLS2) [MIM:209920]; also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
    • 配列類似性Belongs to the RFX family.
      Contains 1 RFX-type winged-helix DNA-binding domain.
    • ドメインThe N-terminus is required for dimer formation, association with RFXANK and RFXAP, assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperative binding between the RFX complex and NF-Y.
    • 翻訳後修飾Phosphorylated.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • DNA binding protein RFX 5 antibody
      • DNA binding protein RFX5 antibody
      • DNA-binding protein RFX5 antibody
      • Influences HLA class II expression antibody
      • Regulatory factor X 5 antibody
      • Regulatory factor X subunit 5 antibody
      • Regulatory factor X, 5 (influences HLA class II expression) antibody
      • RFX 5 antibody
      • RFX5 antibody
      • Rfx5 protein antibody
      • RFX5_HUMAN antibody
      see all

    Anti-RFX5 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab57920 RFX5 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-RFX5 antibody (ab57920) 使用論文

    ab57920 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab57920.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"