Anti-REV3L 抗体 (ab111729)
Key features and details
- Rabbit polyclonal to REV3L
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-REV3L antibody -
製品の詳細
Rabbit polyclonal to REV3L -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Synthetic peptide corresponding to Human REV3L aa 200-300 (internal sequence).
Database link: O60673 -
ポジティブ・コントロール
- Human brain tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
PBS (without Mg2+ and Ca2+) -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
ab111729 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab111729の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis. -
組織特異性
Ubiquitously expressed. -
配列類似性
Belongs to the DNA polymerase type-B family.
Contains 1 CysA-type zinc finger. -
ドメイン
Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 5980 Human
- Entrez Gene: 19714 Mouse
- Omim: 602776 Human
- SwissProt: O60673 Human
- SwissProt: Q61493 Mouse
- Unigene: 232021 Human
- Unigene: 439723 Mouse
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別名
- Catalytic subunit of DNA polymerase zeta antibody
- DNA polymerase zeta catalytic subunit antibody
- DPOLZ_HUMAN antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab111729 は 1 報の論文で使用されています。
- Wang D et al. Lnc-PICSAR contributes to cisplatin resistance by miR-485-5p/REV3L axis in cutaneous squamous cell carcinoma. Open Life Sci 15:488-500 (2020). PubMed: 33817237