製品の概要

  • 製品名Anti-Retinal S antigen antibody
    Retinal S antigen 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Retinal S antigen
  • 特異性Detects recombinant bovine visual Arrestin.
  • アプリケーション適用あり: WB, IP, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Mouse, Sheep, Cow, Human
    交差が予測される動物種: Rat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to Rat Retinal S antigen aa 347-363.
    Sequence:

    EVATEVPFRLMHPQPED


    (Peptide available as ab4974)

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 一次抗体 備考Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to, and interpreted by, the brain. The process of converting light to an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentrations causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin’s activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin. Arrestins are cytosolic proteins that are involved in G protein-coupled receptor (GPCR) desensitization. Arrestin binding to activated GPCRs is phosphorylation dependent and, once bound, uncouple the GPCR from the associated heterotrimeric G proteins. There are currently 4 known mammalian isoforms, beta-Arrestin 1 (Arrestin 2), beta-Arrestin 2 (Arrestin 3), visual Arrestin (Arrestin 1), and cone arrestin. The beta- isoforms are ubiquitously expressed and are known to interact with acetylcholine and adrenergic receptors. Visual and cone Arrestins are found to interact directly with transducin.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab3435 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2 µg/ml. Can be blocked with Retinal S antigen peptide (ab4974).
IP Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.
ICC/IF 1/100.

ターゲット情報

  • 機能Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.
  • 組織特異性Retina and pineal gland.
  • 関連疾患Defects in SAG are a cause of congenital stationary night blindness Oguchi type 1 (CSNBO1) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.
  • 配列類似性Belongs to the arrestin family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 48 kDa protein antibody
    • Arrestin 1 antibody
    • Arrestin antibody
    • ARRS_HUMAN antibody
    • Retinal S antigen (48 KDa protein) antibody
    • Retinal S-antigen antibody
    • Rod photoreceptor arrestin antibody
    • RP47 antibody
    • S antigen antibody
    • S antigen retina and pineal gland (arrestin) antibody
    • S arrestin antibody
    • S-AG antibody
    • S-arrestin antibody
    • SAG antibody
    see all

Anti-Retinal S antigen antibody 画像

  • Western blot on recombinant bovine Retinal S antigen using ab3435.

Anti-Retinal S antigen antibody (ab3435) 使用論文

ab3435 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab3435.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"