製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to RERE
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    KLH conjugated synthetic peptide corresponding to a region within amino acids 389-418 from the N terminal region of Human RERE.

  • ポジティブ・コントロール
    • Neuro-2a cell line lysates; lung carcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab103462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 172 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
  • 組織特異性
    Widely expressed. Expressed in tumor cell lines.
  • 関連疾患
    Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line. Translocation t(1;15)(p36.2;q24).
  • 配列類似性
    Contains 1 BAH domain.
    Contains 1 ELM2 domain.
    Contains 1 GATA-type zinc finger.
    Contains 1 SANT domain.
  • ドメイン
    The interaction with ATN1 is mediated by the coiled coil domain.
  • 細胞内局在
    Nucleus. Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 1110033A15Rik antibody
    • AI414665 antibody
    • ARG antibody
    • arginine glutamic acid dipeptide (RE) repeats antibody
    • arginine glutamic acid dipeptide repeats antibody
    • Arginine glutamic acid dipeptide repeats protein antibody
    • Arginine-glutamic acid dipeptide repeats protein antibody
    • ARGININE-GLUTAMIC ACID REPEATS-ENCODING GENE antibody
    • ARP antibody
    • ATN1L antibody
    • Atr2 antibody
    • atrophin 1 like antibody
    • Atrophin 1 like protein antibody
    • Atrophin 1 related protein antibody
    • atrophin 2 antibody
    • atrophin related protein antibody
    • ATROPHIN-1-ASSOCIATED PROTEIN antibody
    • Atrophin-1-like protein antibody
    • Atrophin-1-related protein antibody
    • atrophin-2 antibody
    • ATROPHIN-RELATED PROTEIN antibody
    • AW742570 antibody
    • DNB1 antibody
    • FLJ38775 antibody
    • KIAA0458 antibody
    • mKIAA0458 antibody
    • NEDBEH antibody
    • OTTHUMP00000001701 antibody
    • Rere antibody
    • RERE_HUMAN antibody
    see all

画像

  • Anti-RERE antibody (ab103462) at 1/100 dilution + Neuro 2a cell line lysate at 35 µg

    Predicted band size : 172 kDa
  • ab103462, at a 1/50 dilution, staining RERE in formalin fixed and paraffin embedded lung carcinoma tissue by Immunohistochemistry. Developed using peroxidase conjugated secondary antibody and DAB staining.

参考文献

ab103462 has not yet been referenced specifically in any publications.

レビューと Q&A

Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Human Tissue sections (brain)
Specification
brain
Fixative
Paraformaldehyde
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: Tris-EDTA-Buffer pH 9,0
Permeabilization
Yes - Wash-Buffer from DAKO with Tween
Username

Mr. Rudolf Jung

Verified customer

投稿 Feb 15 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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