Anti-Reptin/TIP49B/RUVB2 抗体 (ab109872)

製品の概要

• 製品名Anti-Reptin/TIP49B/RUVB2 antibody
  Reptin/TIP49B/RUVB2 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to Reptin/TIP49B/RUVB2
• アプリケーション適用あり: WB, IHC-Pmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat, Cow
• 免疫原

  Recombinant protein (Human)

• ポジティブ･コントロール
  • WB: A431 or H1299 cell lysate. IHC-P: skin, testis, or uterus tissue.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファーPreservative: 0.01% Thimerosal (merthiolate)
  Constituents: 10% Glycerol, 0.1M Tris glycine, pH 7
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • Acetylation

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • DNA Damage Response
  • Other

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Testis (human) normal tissue slides (ab4373)
  • Uterus (human) normal tissue slides (ab4378)
  • A431 whole cell lysate (ab7909)

アプリケーション

ターゲット情報

• 機能Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL2 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2.
• 組織特異性Ubiquitously expressed. Highly expressed in testis and thymus.
• 配列類似性Belongs to the ruvB family.
• ドメインThe C-terminal domain is required for association with ATF2.
• 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
• 細胞内局在Nucleus matrix. Nucleus > nucleoplasm. Cytoplasm. Membrane. Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes.

• Target information above from: UniProt accession Q9Y230 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 511048 Cow
  • Entrez Gene: 10856 Human
  • Entrez Gene: 20174 Mouse
  • Entrez Gene: 292907 Rat
  • Omim: 604788 Human
  • SwissProt: Q2TBU9 Cow
  • SwissProt: Q9Y230 Human
  • SwissProt: Q9WTM5 Mouse

  • Unigene: 515846 Human
  • Unigene: 34410 Mouse
  • Unigene: 136577 Rat

  see all
• 別名
  • 48 kDa TATA box-binding protein-interacting protein antibody
  • 48 kDa TBP-interacting protein antibody
  • 48-kDa TATA box-binding protein-interacting protein antibody

  • 48-kDa TBP-interacting protein antibody
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  • EC=3.6.1.- antibody
  • ECP-51 antibody
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  • Erythrocyte cytosolic protein, 51-KD antibody
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  • INO80J antibody
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  • MGC52995 antibody
  • mp47 antibody
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  • p47 protein antibody
  • Repressing pontin 52 antibody
  • Reptin 52 antibody
  • REPTIN antibody
  • RuvB (E coli homolog)-like 2 antibody
  • RUVB, E. coli, homolog-like 2 antibody
  • RuvB-like 2 (E. coli) antibody
  • RuvB-like 2 antibody
  • RuvB-like protein 2 antibody
  • RUVB2 antibody
  • RUVB2_HUMAN antibody
  • RUVBL2 antibody
  • RVB2 antibody
  • TAP54-beta antibody
  • TATA box-binding protein-interacting protein, 48-KD antibody
  • TBP-interacting protein, 48-KD antibody
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  see all