The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生理活性Biological Activity: ED50 = 1.0-10.0 ng/mL. The biological activity was determined by measuring the dose dependent chemotaxis with human THP-1 cells. The optimal concentration should be determined for each specific application by an initial dose-response assay.
% SDS-PAGE. Purified by proprietary chromatographic techniques.
備考For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sterile solution containing no additives.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
再構成Lyophilized from a concentrated (1mg/ml) sterile solution containing no additives. Reconstitute the lyophilized product in sterile 18MOhm-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
C-C motif chemokine 2
Chemokine (C C motif) ligand 2
Monocyte chemoattractant protein 1
Monocyte chemotactic and activating factor
Monocyte chemotactic protein 1
Monocyte secretory protein JE
Small inducible cytokine A2
Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je)
Small inducible cytokine subfamily A (Cys Cys), member 2
Small-inducible cytokine A2
機能Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
配列類似性Belongs to the intercrine beta (chemokine CC) family.
翻訳後修飾Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.