Recombinant Rat GsaSLeu212 protein (ab90796)

製品の概要

  • 製品名Recombinant Rat GsaSLeu212 protein
  • タンパク質長Full length protein
  • 製品の詳細
    Recombinant Rat GsαSLeu212 protein

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Rat

特性

Our Abpromise guarantee covers the use of ab90796 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

  • 製品の状態Liquid
  • 備考


    The exchange of Gln212 to Leu212 inhibits the intrinsic GTPase activity, resulting in a constitutively activated Galpha, and increases GDP-affinity of Galpha.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 75mM Tris HCl, 12.5mM Magnesium chloride, 1mM EDTA, pH 7.4

関連情報

  • 別名
    • Adenylate cyclase stimulating G alpha protein
    • AHO
    • C20orf45
    • dJ309F20.1.1
    • dJ806M20.3.3
    • Extra large alphas protein
    • GNAS
    • GNAS complex locus
    • GNAS1
    • GPSA
    • Gs alpha subunit
    • GSA
    • GSP
    • Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms short
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms XLas
    • Guanine nucleotide regulatory protein
    • MGC33735
    • PHP1A
    • PHP1B
    • POH
    • Secretogranin VI
    • XLalphas
    see all
  • 関連性Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
  • 細胞内局在Cell membrane; Lipid-anchor

Recombinant Rat GsaSLeu212 protein (ab90796) 使用論文

ab90796 has not yet been referenced specifically in any publications.

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Thank you for contacting Abcam.

The only unmodified version of the protein that we have in our catalogue is ab90723, so that might be the best of them to use. However be aware that although the datasheet says that the protein is full length, ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"