製品の概要

  • 製品名Recombinant rat CHM protein
  • タンパク質長Full length protein

製品の詳細

  • 由来Recombinant
  • 由来Spodoptera frugiperda
  • アミノ酸配列
    • 生物種Rat

特性

Our Abpromise guarantee covers the use of ab91070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Activity: 1 pmol of CHM will mediate transfer of 2 pmol of geranylgeraniol by RabGGTase onto 1 pmol of Rab7 in 3 minutes.
  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 5mM DTT, 40mM Sodium chloride, 25mM HEPES, pH 7.2

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • CHM
    • Chm
    • Choroideraemia protein
    • Choroideremia
    • DXS540
    • FLJ38564
    • GGTA
    • HSD 32
    • MGC102710
    • Rab escort protein 1
    • Rab geranylgeranyltransferase component A
    • Rab proteins geranylgeranyltransferase component A 1
    • RAE1_HUMAN
    • REP 1
    • REP-1
    • REP1
    • TCD
    • TCD protein
    see all
  • 機能Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
  • 関連疾患Defects in CHM are the cause of choroideremia (CHM) [MIM:303100]. An X-linked recessive disease characterized by a slowly progressive degeneration of the choroid, photoreceptors, and retinal pigment epithelium. Affected males develop night blindness in their teenage years followed by loss of peripheral vision and complete blindness at middle age. Carrier females are generally asymptomatic but funduscopic examination often shows patchy areas of chorioretinal atrophy.
  • 配列類似性Belongs to the Rab GDI family.
  • Information by UniProt

Recombinant rat CHM protein (ab91070) 使用論文

ab91070 has not yet been referenced specifically in any publications.

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