cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A
cAMP and cAMP-inhibited cGMP 3''
機能Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
組織特異性Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
配列類似性Belongs to the cyclic nucleotide phosphodiesterase family. Contains 2 GAF domains.
ドメインThe tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity. Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region.
細胞内局在Cytoplasm. Located mostly to soluble cellular fractions.