Recombinant p15 Treponema pallidum protein (Beta-Galactosidase) (ab49008)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 配列の追加情報Fused with β-galactosidase at the N-terminus.

特性

Our Abpromise guarantee covers the use of ab49008 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Reacts strongly with human T. pallidum positive serum.
  • アプリケーション

    ELISA

    Western blot

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • 備考Reacts strongly with human T. pallidum positive serum.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8

関連情報

  • 別名
    • 15 kDa lipoprotein
    • 15 kDa lipoprotein precursor (Major membrane immunogen)
    • Major membrane immunogen
    • tpp15
    • Treponema Pallidum Lipoprotein Immunogen p15
    see all
  • 関連性The 15 kDa lipoprotein of Treponema pallidum is a major immunogen during natural syphilis infection in humans and experimental infection in other hosts. The humoral and cellular immune responses to this molecule appear late in infection as resistance to reinfection is developing. The complete genome sequence of Treponema pallidum has been determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. Treponema pallidum is a gram-negative spirochaete bacterium and there are at least four known subspecies: T. pallidum pallidum, which causes syphilis; T. pallidum pertenue, which causes yaws; T. pallidum carateum, which causes pinta; and T. pallidum endemicum, which causes bejel. There is no vaccine for syphilis. The outer membrane of T. pallidum has too few surface proteins for an antibody to be effective. Efforts to develop a safe and effective syphilis vaccine have been hindered by uncertainty about the relative importance of humoral and cellular mechanisms to protective immunity and the fact that T. pallidum outer membrane proteins have not been unambiguously identified.
  • 細胞内局在Bacterial cell membrane; lipid-anchor (Probable).

Recombinant p15 Treponema pallidum protein (Beta-Galactosidase) (ab49008) 使用論文

ab49008 has not yet been referenced specifically in any publications.

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