Recombinant Mouse VEGFC protein (ab51947)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Suitable for: SDS-PAGE
製品の詳細
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製品名
Recombinant Mouse VEGFC protein
VEGFC タンパク質・ペプチド 製品一覧 -
精製度
> 90 % SDS-PAGE.
>90% by SDS-PAGE analyses. -
発現系
Escherichia coli -
タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Mouse -
配列
HY NTEILKSIDN EWRKTQCMPR EVCIDVGKEF GAATNTFFKPPCVSVYRCGG CCNSEGLQCM NTSTGYLSKTLFEITVPLSQ GPKPVTISFANHTSCRCMSK LDVYRQVHSI IRR -
領域
108 to 223
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特性
Our Abpromise guarantee covers the use of ab51947 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
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製品の状態
Lyophilized -
備考
This product is manufactured by BioVision, an Abcam company and was previously called 4634 VEGF-C, murine recombinant. 4634-10 is the same size as the 10 µg size of ab51947.
Reconstituted VEGFC should be stored in working aliquots at -80°C.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Constituent: 0.1% Acetic acid
50 µg BSA per 1 µg VEGFC -
再構成We recommend a quick spin followed by reconstitution in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml.
関連情報
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別名
- Flt 4L
- Flt4 ligand
- FLT4 ligand DHM
see all -
機能
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. -
組織特異性
Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. -
配列類似性
Belongs to the PDGF/VEGF growth factor family. -
翻訳後修飾
Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. -
細胞内局在
Secreted. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (1)
ab51947 は 1 報の論文で使用されています。
- Nayar S et al. Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin a1ß2 in Newly Formed Tertiary Lymphoid Structures. J Immunol 197:1957-67 (2016). PubMed: 27474071