Recombinant mouse Tau tubulin kinase 2 protein (ab125631)

製品の概要

  • 製品名Recombinant mouse Tau tubulin kinase 2 protein
  • タンパク質長Protein fragment

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号Q3UVR3
    • 生物種Mouse
    • 分子量88 kDa including tags
    • 領域70 to 538
    • タグGST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab125631 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The specific activity of ab125631 was determined to be 370 nmol/min/mg.
  • アプリケーション

    Western blot

    Functional Studies

    SDS-PAGE

  • 精製度> 95 % Densitometry.
    >95% by Densitometry,
  • 製品の状態Liquid
  • 備考

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • KIAA0847
    • mKIAA0847
    • SCA11
    • Spinocerebellar ataxia 11
    • Tau tubulin kinase 2
    • Tau-tubulin kinase 2
    • TTBK
    • TTBK 2
    • TTBK1
    • TTBK2
    • TTBK2_HUMAN
    • TTK
    see all
  • 機能Serine/threonine kinase which is able to phosphorylate tau on serines.
  • 関連疾患Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11) [MIM:604432]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder.
  • 配列類似性Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Information by UniProt

Recombinant mouse Tau tubulin kinase 2 protein 画像

  • SDS-PAGE of ab125631
  • The specific activity of ab125631 was determined to be 370 nmol/min/mg.

Recombinant mouse Tau tubulin kinase 2 protein (ab125631) 使用論文

ab125631 has not yet been referenced specifically in any publications.

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