The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. >98% by SDS-PAGE and HPLC analyses.
備考The reconstituted solution can be diluted into aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Concentration information loading...
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Lyophilized from 75mM Sodium chloride, 5mM Tris, pH 7.6
Endotoxin is <0.1 ng/µg of sRANKL.
再構成Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg /ml.
Osteoclast differentiation factor
Receptor activator of nuclear factor kappa B ligand
Receptor activator of nuclear factor kappa-B ligand
TNF related activation induced cytokine
TNF-related activation-induced cytokine
Tumor necrosis factor (ligand) superfamily member 11
Tumor necrosis factor ligand superfamily member 11
Tumor necrosis factor ligand superfamily member 11, soluble form
機能Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
組織特異性Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
関連疾患Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2) [MIM:259710]; also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.
配列類似性Belongs to the tumor necrosis factor family.
翻訳後修飾The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.