The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生理活性One unit of protease hydrolyzes 1 picomole of Mouse renin FRET substrate 5-FAM/QXLTM 520 per minute at pH 7.5 at 25° C.
One unit of protease hydrolyzes 1 picomole of Mouse renin FRET substrate 5-FAM/QXLTM 520 per minute at pH 7.5 at 25° C.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituent: 0.6% Tris
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Angiotensin forming enzyme
Renin precursor renal
機能Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
関連疾患Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
配列類似性Belongs to the peptidase A1 family.
細胞内局在Secreted. Membrane. Associated to membranes via binding to ATP6AP2.