Recombinant mouse Prorenin protein (ab123479)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    HEK 293 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Mouse
    • 分子量
      42 kDa including tags
    • 領域
      1 to 402
    • タグ
      His tag C-Terminus

特性

Our Abpromise guarantee covers the use of ab123479 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    One unit of protease hydrolyzes 1 picomole of Mouse renin FRET substrate 5-FAM/QXLTM 520 per minute at pH 7.5 at 25° C.
  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 製品の状態
    Liquid
  • 備考
    One unit of protease hydrolyzes 1 picomole of Mouse renin FRET substrate 5-FAM/QXLTM 520 per minute at pH 7.5 at 25° C.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituent: 0.6% Tris

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Angiotensin forming enzyme
    • Angiotensinogenase
    • FLJ10761
    • HNFJ2
    • REN
    • Ren1
    • RENAA
    • RENI_HUMAN
    • Renin
    • Renin precursor renal
    • Renin-1
    • Renin-2
    see all
  • 機能
    Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
  • 関連疾患
    Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
  • 配列類似性
    Belongs to the peptidase A1 family.
  • 細胞内局在
    Secreted. Membrane. Associated to membranes via binding to ATP6AP2.
  • Information by UniProt

参考文献

ab123479 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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