製品の概要

製品の詳細

  • 由来Recombinant
  • 由来HEK 293 cells
  • アミノ酸配列
    • アクセッション番号Q9EPU5
    • 生物種Mouse
    • 分子量80 kDa
    • 領域42 to 348

特性

Our Abpromise guarantee covers the use of ab109063 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • エンドトキシン・レベル< 0.100 Eu/µg
  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Lyophilised
  • 備考PBS containing at least 0.1% BSA should be used for further dilutions.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C.

    Preservative: None
    Constituents: PBS

  • 再構成Reconstitute with 50 µl sterile water.

関連情報

  • 別名
    • TNFRSF 21
    • BM 018
    • BM018
    • CD358
    • Death receptor 6
    • DR 6
    • DR6
    • MGC31965
    • OTTHUMP00000039915
    • TNFR related death receptor 6
    • TNFRSF21
    • TNFRSF21 protein
    • TNR21_HUMAN
    • Tumor necrosis factor receptor superfamily member 21
    • Tumor necrosis factor receptor superfamily member 21 precursor
    see all
  • 機能May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
  • 組織特異性Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
  • 配列類似性Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • 細胞内局在Membrane.
  • Information by UniProt

Recombinant Mouse DR6 protein (ab109063) 使用論文

ab109063 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab109063.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"