製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Mouse
    • 分子量
      35 kDa including tags
    • 領域
      1 to 272
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab113191 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.
    ab113191 is purified by multi-step chromatography.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.50
    Constituents: 0.61% Tris, 0.03% DTT, 0.03% EDTA, 1.46% Sodium chloride

関連情報

  • 別名
    • Dickkopf 1
    • Dickkopf 1 homolog
    • Dickkopf 1 like
    • Dickkopf homolog 1
    • Dickkopf like protein 1
    • Dickkopf related protein 1
    • Dickkopf WNT signaling pathway inhibitor 1
    • Dickkopf-1
    • Dickkopf-related protein 1
    • DKK 1
    • Dkk-1
    • Dkk1
    • DKK1_HUMAN
    • hDkk 1
    • hDkk-1
    • SK
    see all
  • 機能
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 組織特異性
    Placenta.
  • 配列類似性
    Belongs to the dickkopf family.
  • ドメイン
    The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • 細胞内局在
    Secreted.
  • Information by UniProt

画像

  • anti-DKK1 pAb + Recombinant Mouse DKK1 protein (ab113191) at 0.01 µg
    Developed using the ECL technique
  • SDS-PAGE showing ab113191
    Lane 1: 0.5 mg protein
    Lane 2: 1.0 mg protein
    Lane 3: 2.0 mg protein
    Lane 4: 5.0 mg protein

参考文献

ab113191 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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