The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological Activity : The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.5-0.8 µg/ml.
< 0.100 Eu/µg
% SDS-PAGE. Purity is greater than 98% by SDS-PAGE and HPLC analyses.
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
CTF2, also known as Neuropoietin is a newly identified member of the IL6 cytokine family. CTF2 increases the platelet count associated with splenomegaly and may have an important role in neuronal precursor development and maturation.
CTF2, which is predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex comprising CNTF receptor-a component, gp 130, and LIF receptor. Interestingly, the human Neuropoietin gene has evolved toward a pseudogene, suggesting that the alternative signaling via CNTF is an effective compensatory pathway.
has not yet been referenced specifically in any publications.