製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Mouse

特性

Our Abpromise guarantee covers the use of ab58730 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 250mM Imidizole, PBS

関連情報

  • 別名
    • AI325008
    • BAD
    • BAD_HUMAN
    • BBC 2
    • BBC2
    • BBC6
    • Bcl 2 Antagonist of Cell Death
    • Bcl 2 Binding Component 6
    • BCL X / BCL 2 Binding Protein
    • BCL X Binding Protein
    • Bcl XL/Bcl 2 Associated Death Promoter
    • Bcl-2-binding component 6
    • Bcl-2-like protein 8
    • Bcl-XL/Bcl-2-associated death promoter
    • Bcl2 antagonist of cell death
    • BCL2 antagonist of cell death protein
    • BCL2 associated agonist of cell death
    • Bcl2 Associated Death Promoter
    • BCL2 binding component 6
    • BCL2 binding protein
    • Bcl2 Like 8 Protein
    • Bcl2-L-8
    • BCL2L8
    • Proapoptotic BH3 Only Protein
    see all
  • 機能
    Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
  • 組織特異性
    Expressed in a wide variety of tissues.
  • 配列類似性
    Belongs to the Bcl-2 family.
  • ドメイン
    Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
  • 翻訳後修飾
    Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Ser-75 is phosphorylated by AKT/PKB, protein kinase A and PIM2.
  • 細胞内局在
    Mitochondrion outer membrane. Cytoplasm. Upon phosphorylation, locates to the cytoplasm.
  • Information by UniProt

参考文献

ab58730 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab58730.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録