製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab60963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

  • 製品の状態Liquid
  • 備考

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • 70 kDa zeta associated protein
    • 70 kDa zeta-associated protein
    • EC 2.7.10.2
    • FLJ17670
    • FLJ17679
    • Selective T cell defect
    • SRK
    • STD
    • Syk related tyrosine kinase
    • Syk-related tyrosine kinase
    • Truncated ZAP kinase
    • Tyrosine protein kinase ZAP70
    • Tyrosine-protein kinase ZAP-70
    • TZK
    • ZAP 70
    • ZAP70
    • ZAP70_HUMAN
    • Zeta chain associated protein kinase 70kD
    • Zeta chain associated protein kinase 70kDa
    • Zeta chain associated protein kinase 70kDa isoform 1
    • Zeta chain associated protein kinase 70kDa isoform 2
    • Zeta chain TCR associated protein kinase 70kD
    • Zeta chain TCR associated protein kinase 70kDa
    see all
  • 機能Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.
  • 組織特異性Expressed in T- and natural killer cells.
  • 関連疾患Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
    Contains 1 protein kinase domain.
    Contains 2 SH2 domains.
  • ドメインThe SH2 domains bind to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z and the non-canonical phosphorylated tyrosine-based activation motif (TAM) of RHOH.
  • 翻訳後修飾Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity.
  • 細胞内局在Cytoplasm. Cell membrane. After antigen stimulation, isoform 1 concentrates at the immunological synapse and isoform 2 remains cytoplasmic. Co-localizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes.
  • Information by UniProt

Recombinant human ZAP70 protein 画像

Recombinant human ZAP70 protein (ab60963) 使用論文

ab60963 has not yet been referenced specifically in any publications.

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