製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab89852 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性The specific activity of ab89852 was determined to be 62 nmol/min/mg
  • アプリケーション

    SDS-PAGE

    Western blot

    Functional Studies

  • 製品の状態Liquid
  • 備考

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • AZK
    • Cervical cancer suppressor gene 4 protein
    • HCCS 4
    • HCCS-4
    • HCCS4
    • Human cervical cancer suppressor gene 4 protein
    • Leucine zipper and sterile alpha motif containing kinase
    • Leucine zipper- and sterile alpha motif-containing kinase
    • Mitogen activated protein kinase kinase kinase MLT
    • Mitogen-activated protein kinase kinase kinase MLT
    • Mixed lineage kinase 7
    • Mixed lineage kinase related kinase
    • Mixed lineage kinase related kinase MRK beta
    • Mixed lineage kinase with a leucine zipper and a sterile alpha motif
    • Mixed lineage kinase-related kinase
    • MLK 7
    • MLK like mitogen activated protein triple kinase
    • MLK related kinase
    • MLK-like mitogen-activated protein triple kinase
    • MLK-related kinase
    • MLK7
    • Mlklak
    • MLT
    • MLTK_HUMAN
    • MRK
    • Sterile alpha motif and leucine zipper containing kinase AZK
    • Sterile alpha motif- and leucine zipper-containing kinase AZK
    • ZAK
    see all
  • 機能Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
  • 組織特異性Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
  • 配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • 細胞内局在Cytoplasm. Nucleus. Translocates to the nucleus upon ultraviolet B irradiation.
  • Information by UniProt

Recombinant human ZAK protein 画像

  • SDS-PAGE showing ab89852 at approximately 82kDa
  • Kinase Assay demonstrating specific activity of ab89852

Recombinant human ZAK protein (ab89852) 使用論文

ab89852 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab89852.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"