製品の概要
- 製品名Recombinant Human XIAP protein
XIAP タンパク質・ペプチド 製品一覧 - タンパク質長Full length protein
法規制情報
製品の詳細
- 由来Recombinant
- 由来Baculovirus infected Sf9 cells
- アミノ酸配列
- アクセッション番号P98170
- 生物種Human
- 分子量84 kDa including tags
- 領域1 to 497
関連製品
- Related Products
特性
Our Abpromise guarantee covers the use of ab125537 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- アプリケーション
Western blot
SDS-PAGE
- 精製度> 70
% Densitometry.
Purity determined to be >70% by densitometry. - 製品の状態Liquid
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Concentration information loading...
前処理および保存
- 保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride
関連情報
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別名
- AP 13
- API3
- Apoptosis Inhibitor 3
see all - 機能Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B.
- 組織特異性Ubiquitous, except peripheral blood leukocytes.
- 関連疾患Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2) [MIM:300635]. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
- 配列類似性Belongs to the IAP family.
Contains 3 BIR repeats.
Contains 1 RING-type zinc finger. - ドメインThe first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated by the second and third BIR domains.
- 翻訳後修飾Ubiquitinated and degraded by the proteasome in apoptotic cells.
Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against proteasomal degradation. - 細胞内局在Cytoplasm.
- Information by UniProt
Recombinant Human XIAP protein 画像
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SDS-PAGE - XIAP protein (Tagged) (ab125537)SDS-PAGE analysis of ab125537.
Recombinant Human XIAP protein (ab125537) 使用論文
ab125537 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"