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別名
- AP 13
- API3
- Apoptosis Inhibitor 3
- Baculoviral IAP repeat containing 4
- Baculoviral IAP Repeat Containing Protein 4
- Baculoviral IAP repeat-containing protein 4
- BIRC 4
- BIRC4
- E3 ubiquitin-protein ligase XIAP
- hIAP-3
- hIAP3
- HILP
- IAP 3
- IAP like protein
- IAP-3
- IAP-like protein
- IAP3
- ILP
- ILP 1
- ILP1
- Inhibitor of apoptosis protein 3
- Inhibitor of Apoptosis X Linked
- Mammalian IAP Homologue A
- MIHA
- X linked IAP
- X linked inhibitor of apoptosis
- X linked inhibitor of apoptosis E3 ubiquitin protein ligase
- X linked inhibitor of apoptosis protein
- X-linked IAP
- X-linked inhibitor of apoptosis protein
- Xiap
- XIAP_HUMAN
- XLP2
see all
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機能
Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B.
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組織特異性
Ubiquitous, except peripheral blood leukocytes.
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関連疾患
Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2) [MIM:300635]. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
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配列類似性
Belongs to the IAP family.
Contains 3 BIR repeats.
Contains 1 RING-type zinc finger.
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ドメイン
The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated by the second and third BIR domains.
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翻訳後修飾
Ubiquitinated and degraded by the proteasome in apoptotic cells.
Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against proteasomal degradation.
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細胞内局在
Cytoplasm.
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Information by UniProt