製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus
  • アミノ酸配列
    • アクセッション番号Q9H0M0
    • 生物種Human
    • 分子量106 kDa including tags
    • 領域2 to 922
    • タグDDDDK tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab95931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on Dry Ice. Store at -80°C.

    pH: 8.00
    Constituents: 20% Glycerol, 0.58% Sodium chloride, 0.395% Tris HCl, 0.05% Tween, 0.0462% DTT
    Note: 103 µg/ml FLAG peptide

関連情報

  • 別名
    • AIP 5
    • AIP5
    • Atropin-1-interacting protein 5
    • hSDRP1
    • Nedd 4 like ubiquitin protein ligase
    • nedd4 like
    • NEDD4-like E3 ubiquitin-protein ligase WWP1
    • TGIF interacting ubiquitin ligase 1
    • Tiul1
    • WW domain containing E3 ubiquitin protein ligase 1
    • WW domain-containing protein 1
    • WWP 1
    see all
  • 関連性WWP1 is an E3 ubiquitin ligase and belongs to a family of NEDD4-like proteins. WWP1 contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The HECT domain of WWP1 has been implicated in regulating the localization and stability of p53 – inhibition of WWP1 results in a decrease in p53 expression, whilst WWP1 mediated stabilization of p53 appears to be associated with an accumulation of cytoplasmic p53. WWP1 also negatively regulates the TGF beta tumor suppressor pathway by inactivating its molecular components (SMAD2, SMAD4 and TGFbetaR1). WWP1 has been implicated in both breast and prostate cancers.
  • 細胞内局在Cell Membrane, Cytoplasmic and Nuclear

Recombinant Human WWP1 protein 画像

  • 10% SDS-PAGE showing ab95931 at approximately 106kDa (1µg).

Recombinant Human WWP1 protein (ab95931) 使用論文

ab95931 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab95931.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"