製品の概要

  • 製品名
    Recombinant human WISP1 protein
  • タンパク質長
    Full length protein

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      TALSPAPTTM DFTPAPLEDT SSRPQFCKWP CECPPSPPRC PLGVSLITDG CECCKMCAQQ LGDNCTEAAI CDPHRGLYCD YSGDRPRYAI GVCAQVVGVG CVLDGVRYNN GQSFQPNCKY NCTCIDGAVG CTPLCLRVRP PRLWCPHPRR VSIPGHCCEQ WVCEDDAKRP RKTAPRDTGA FDAVGEVEAW HRNCIAYTSP WSPCSTSCGL GVSTRISNVN AQCWPEQESR LCNLRPCDVD IHTLIKAGKK CLAVYQPEAS MNFTLAGCIS TRSYQPKYCG VCMDNRCCIP YKSKTIDVSF QCPDGLGFSR QVLWINACFC NLSCRNPNDI FADLESYPDF SEIAN

特性

Our Abpromise guarantee covers the use of ab50041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Biological Activity : The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 1.0-3.0 µg/ml.
  • アプリケーション

    SDS-PAGE

    Functional Studies

  • エンドトキシン・レベル
    < 0.100 Eu/µg
  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

    Preservative: None
    Constituents: 10mM Acetic acid

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成
    Reconstitute product with 10mM Acetic Acid.

関連情報

  • 別名
    • CCN 4
    • CCN family member 4
    • CCN4
    • WISP 1
    • WISP 1c
    • WISP 1i
    • WISP 1tc
    • WISP1c
    • WISP1i
    • WISP1tc
    • Wnt 1 induced secreted protein
    • WNT 1 induced secreted protein 1
    • WNT 1 inducible signaling pathway protein 1
    • Wnt 1 signaling pathway protein 1
    • Wnt-1 inducible signaling pathway protein 1
    • Wnt1 induced secreted protein
    • WNT1 induced secreted protein 1
    • WNT1 inducible signaling pathway protein 1
    • Wnt1 signaling pathway protein 1
    • WNT1-inducible-signaling pathway protein 1
    see all
  • 関連性
    WISP1 is a downstream regulator in the Wnt/Frizzled-signaling pathway and is associated with cell survival. WISP1 attentuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase and up-regulates the anti-apoptotic Bcl-X(L) protein. WISP1 is expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Overexpression is associated with several cancers including breast cancer and colon tumors.
  • 細胞内局在
    Secreted

参考文献

This product has been referenced in:
  • Li WF  et al. WISP-1 contributes to fractionated irradiation-induced radioresistance in esophageal carcinoma cell lines and mice. PLoS One 9:e94751 (2014). ICC/IF ; Mouse, Human . Read more (PubMed: 24728101) »

See 1 Publication for this product

ab50041 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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