製品の概要

  • 製品名
    Recombinant Human WHSC2 protein
  • タンパク質長
    Full length protein

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHMPGQRRALSPKMASMRESDTGLWLHNKLGA TDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVD EMKGALMEIIQLASLDSDPWVLMVADILKSFPDTGSLNLELEEQNPNVQD ILGELREKVGECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKP KSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMDTTTPLKGIPK QAPFRSPTAPSVFSPTGNRTPIPPSRTLLRKERGVKLLDISELDMVGAGR EAKRRRKTLDAEVVEKPAKEETVVENATPDYAAGLVSTQKLGSLNNEPAL PSTSYLPSTPSVVPASSYIPSSETPPAPSSREASRPPEEPSAPSPTLPAQ FKQRAPMYNSGLSPATPTPAAPTSPLTPTTPPAVAPTTQTPPVAMVAPQT QAPAQQQPKKNLSLTREQMFAAQEMFKTANKVTRPEKALILGFMAGSREN PCQEQGDVIQIKLSEHTEDLPKADGQGSTTMLVDTVFEMNYATGQWTRFK KYKPMTNVS
    • 分子量
      61 kDa including tags
    • 領域
      1 to 539
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab116197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度
    > 85 % SDS-PAGE.
    ab116197 was purified using conventional chromatography techniques.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 1.17% Sodium chloride, 0.08% DTT, 0.03% EDTA, 20% Glycerol

関連情報

  • 別名
    • FLJ10442
    • FLJ25112
    • Negative elongation factor A
    • Negative elongation factor polypeptide A
    • NELF A
    • NELF-A
    • NELFA
    • NELFA_HUMAN
    • P/OKcl.15
    • P/OKcl15
    • WHSC 2
    • Whsc2
    • Wolf Hirschhorn syndrome candidate 2
    • Wolf Hirschhorn syndrome candidate 2 protein
    • Wolf-Hirschhorn syndrome candidate 2 protein
    see all
  • 機能
    Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex.
  • 組織特異性
    Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney.
  • 配列類似性
    Belongs to the NELF-A family.
    Contains 1 HDAg-like domain.
  • ドメイン
    The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the RNA polymerase II complex.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

画像

  • 15% SDS-PAGE analysis of 3 µg ab116197.

参考文献

ab116197 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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